The Bilayer Collective Properties Govern the Interaction of an HIV-1 Antibody with the Viral Membrane.

ABSTRACT: Efficient engagement with the envelope glycoprotein membrane-proximal external region (MPER) results in robust blocking of viral infection by a class of broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus (HIV). Developing an accommodation surface that engages with the viral lipid envelope appears to correlate with the neutralizing potency displayed by these bnAbs. The nature of the interactions established between the antibody and the lipid is nonetheless a matter of debate, with some authors arguing that anti-MPER specificity arises only under pathological conditions in autoantibodies endowed with stereospecific binding sites for phospholipids. However, bnAb-lipid interactions are often studied in systems that do not fully preserve the biophysical properties of l

SUBMITTER: Carravilla P 

PROVIDER: S-EPMC6950647 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature