Assessing genomic diversity and signatures of selection in Original Braunvieh cattle using whole-genome sequencing data.

ABSTRACT:

Background

Autochthonous cattle breeds are an important source of genetic variation because they might carry alleles that enable them to adapt to local environment and food conditions. Original Braunvieh (OB) is a local cattle breed of Switzerland used for beef and milk production in alpine areas. Using whole-genome sequencing (WGS) data of 49 key ancestors, we characterize genomic diversity, genomic inbreeding, and signatures of selection in Swiss OB cattle at nucleotide resolution.

Results

We annotated 15,722,811 SNPs and 1,580,878 Indels including 10,738 and 2763 missense deleterious and high impact variants, respectively, that were discovered in 49 OB key ancestors. Six Mendelian trait-associated variants that were previously detected in breeds other than OB, segregated

SUBMITTER: Bhati M 

PROVIDER: S-EPMC6950892 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature