Dietary methionine influences therapy in mouse cancer models and alters human metabolism.

ABSTRACT: Nutrition exerts considerable effects on health, and dietary interventions are commonly used to treat diseases of metabolic aetiology. Although cancer has a substantial metabolic component¹, the principles that define whether nutrition may be used to influence outcomes of cancer are unclear². Nevertheless, it is established that targeting metabolic pathways with pharmacological agents or radiation can sometimes lead to controlled therapeutic outcomes. By contrast, whether specific dietary interventions can influence the metabolic pathways that are targeted in standard cancer therapies is not known. Here we show that dietary restriction of the essential amino acid methionine-the reduction of which has anti-ageing and anti-obesogenic properties-influences cancer outcome

SUBMITTER: Gao X 

PROVIDER: S-EPMC6951023 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature