SOD2 ameliorates pulmonary hypertension in a murine model of sleep apnea via suppressing expression of NLRP3 in CD11b+ cells.

ABSTRACT: BACKGROUND:High prevalence of obstructive sleep apnea (OSA) in the pulmonary hypertension (PH) population suggests that chronic intermittent hypoxia (CIH) is an important pathogenic factor of PH. However, the exact mechanism of CIH induced PH is not clear. One of the molecules that plays a key role in regulating pulmonary artery function under hypoxic conditions is superoxide dismutase 2 (SOD2). METHODS:Our study utilized heterozygous SOD2-/+ mice firstly in CIH model to explore the exact role of SOD2 in CIH causing PH. Expression of SOD2 was analyzed in CIH model. Echocardiography and pulmonary hypertension were measured in wild type (WT) and SOD2-/+ mice under normal air or CIH condition. Hematoxylin-Eosin (H&E) staining and masson staining were carried out to evaluate pulmonary vascular

SUBMITTER: Fu C 

PROVIDER: S-EPMC6951024 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature