Ontology highlight
ABSTRACT:
SUBMITTER: Dedic N
PROVIDER: S-EPMC6951443 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Nature neuroscience 20180521 6
The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by posi ...[more]