Irreversible and sustained upregulation of endothelin axis during oncogene-associated pancreatic inflammation and cancer.

ABSTRACT: Endothelin-1 (ET-1) and its two receptors, endothelin receptor A (ET_AR) and endothelin receptor B (ET_BR) exhibit deregulated overexprerssion in pancreatic ductal adenocarcinoma (PDAC) and pancreatitis. We examined the expression pattern of endothelin (ET) axis components in the murine models of chronic and acute inflammation in the presence or absence of oncogenic K-ras. While the expression of endothelin converting enzyme-1 (ECE-1), ET-1, ET_AR and ET_BR in the normal pancreas is restricted predominantly to the islet cells, progressive increase of ET receptors in ductal cells and stromal compartment is observed in the KC model (Pdx-1 Cre; K-ras^G12D) of PDAC. In the murine pancreas harboring K-ras^G12D mutation (KC mice), follo

SUBMITTER: Gupta S 

PROVIDER: S-EPMC6951489 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature