Novel eye genes systematically discovered through an integrated analysis of mouse transcriptomes and phenome.

ABSTRACT: In the last few decades, reverse genetic and high throughput approaches have been frequently applied to the mouse (Mus musculus) to understand how genes function in tissues/organs and during development in a mammalian system. Despite these efforts, the associated phenotypes for the majority of mouse genes remained to be fully characterized. Here, we performed an integrated transcriptome-phenome analysis by identifying coexpressed gene modules based on tissue transcriptomes profiled with each of various platforms and functionally interpreting these modules using the mouse phenotypic data. Consequently, >15,000 mouse genes were linked with at least one of the 47 tissue functions that were examined. Specifically, our approach predicted >50 genes previously unknown to be involved in mic

SUBMITTER: Chiang CY 

PROVIDER: S-EPMC6951830 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature