Repeatability of Quantitative 18F-NaF PET: A Multicenter Study.

ABSTRACT: ¹⁸F-NaF, a PET radiotracer of bone turnover, has shown potential as an imaging biomarker for assessing the response of bone metastases to therapy. This study aimed to evaluate the repeatability of ¹⁸F-NaF PET-derived SUV imaging metrics in individual bone lesions from patients in a multicenter study.

Methods

Thirty-five castration-resistant prostate cancer patients with multiple metastases underwent 2 whole-body (test-retest) ¹⁸F-NaF PET/CT scans 3 ± 2 d apart from 1 of 3 imaging sites. A total of 411 bone lesions larger than 1.5 cm³ were automatically segmented using an SUV threshold of 15 g/mL. Two levels of analysis were performed: lesion-level, in which measures were extracted from individual-lesion regions of interest (ROI), and patie

SUBMITTER: Lin C 

PROVIDER: S-EPMC6952054 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature