Harvesting of Prebiotic Fructooligosaccharides by Nonbeneficial Human Gut Bacteria.

ABSTRACT: Prebiotic oligosaccharides, such as fructooligosaccharides, are increasingly being used to modulate the composition and activity of the gut microbiota. However, carbohydrate utilization analyses and metagenomic studies recently revealed the ability of deleterious and uncultured human gut bacterial species to metabolize these functional foods. Moreover, because of the difficulties of functionally profiling transmembrane proteins, only a few prebiotic transporters have been biochemically characterized to date, while carbohydrate binding and transport are the first and thus crucial steps in their metabolization. Here, we describe the molecular mechanism of a phosphotransferase system, highlighted as a dietary and pathology biomarker in the human gut microbiome. This transporter is encoded by

SUBMITTER: Wang Z 

PROVIDER: S-EPMC6952197 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature