Pregnancy-related events associated with subclinical cardiovascular disease burden in late midlife: SWAN.

ABSTRACT:

Background and aims

Reproductive factors are associated with later life CVD in women (e.g., age at first birth, preeclampsia, gestational diabetes), but studies have focused largely on premenopausal women. We examined the relationship of reproductive factors with subclinical CVD burden in late midlife women.

Methods

We included 964 parous women from the Study of Women's Health Across the Nation (SWAN), who completed a reproductive history questionnaire at the 13th SWAN visit (2011-2012), and a carotid ultrasound and brachial-ankle pulse wave velocity (baPWV) assessment. The primary outcomes were carotid intima-media thickness, plaque, and baPWV; our secondary outcome was a composite subclinical CVD index created using these measures. Linear and logistic regression was perfor

SUBMITTER: Cortes YI 

PROVIDER: S-EPMC6952268 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature