Efficacy of atomoxetine versus midodrine for neurogenic orthostatic hypotension.

ABSTRACT:

Objective

The efficacy and safety of 1-month atomoxetine and midodrine therapies were compared. Three-month atomoxetine and combination therapies were investigated for additional benefits.

Methods

This prospective open-label randomized trial included 50 patients with symptomatic neurogenic orthostatic hypotension (nOH). The patients received either atomoxetine 18 mg daily or midodrine 5 mg twice daily and were evaluated 1 and 3 months later. Those who still met the criteria for nOH at 1 month received both midodrine and atomoxetine for an additional 2 months, and if not, they continued their initial medication. The primary outcome was an improvement in orthostatic blood pressure (BP) drop (maximum BP change from supine to 3 min after standing) at 1 month. The secondary endpo

SUBMITTER: Byun JI 

PROVIDER: S-EPMC6952305 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature