High-resolution metabolomic profiling of Alzheimer's disease in plasma.

ABSTRACT:

Background

Alzheimer's disease (AD) is a complex neurological disorder with contributions from genetic and environmental factors. High-resolution metabolomics (HRM) has the potential to identify novel endogenous and environmental factors involved in AD. Previous metabolomics studies have identified circulating metabolites linked to AD, but lack of replication and inconsistent diagnostic algorithms have hindered the generalizability of these findings. Here we applied HRM to identify plasma metabolic and environmental factors associated with AD in two study samples, with cerebrospinal fluid (CSF) biomarkers of AD incorporated to achieve high diagnostic accuracy.

Methods

Liquid chromatography-mass spectrometry (LC-MS)-based HRM was used to identify plasma and CSF metabolites as

SUBMITTER: Niedzwiecki MM 

PROVIDER: S-EPMC6952314 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature