Nigrosome 1 imaging in REM sleep behavior disorder and its association with dopaminergic decline.

ABSTRACT:

Objectives

Rapid eye movement sleep behavior disorder (RBD) patients have a high risk of developing a Parkinsonian disorder, offering an opportunity for neuroprotective intervention. Predicting near-term conversion, however, remains a challenge. Dopamine transporter imaging, while informative, is expensive and not widely available. Here, we investigate the utility of susceptibility-weighted MRI (SWI) to detect abnormalities of the substantia nigra in RBD, and explore their association with striatal dopaminergic deficits.

Methods

SWI of the substantia nigra was performed in 46 RBD patients, 27 Parkinson's patients, and 32 control subjects. Dorsal nigral hyperintensity (DNH) was scored by two blinded raters, and separately quantified using a semiautomated process. Forty-two RB

SUBMITTER: Barber TR 

PROVIDER: S-EPMC6952317 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature