Effects of the monoamine stabilizer (-)OSU6162 on cognitive function in alcohol dependence.

ABSTRACT:

Introduction

Alcohol dependence (AD) is associated with a dysregulated mesolimbocortical dopamine system-a pathway which is also implicated in both reward and cognition. The monoamine stabilizer (-)-OSU6162 (OSU) is a novel pharmacological compound with the ability to reduce ethanol intake and ethanol seeking in long-term drinking rats as well as reducing alcohol craving in AD patients. Dopaminergic drugs can both impair and improve cognitive functions, and the aim of the current study was to investigate the effect of OSU treatment on cognitive functioning in AD patients.

Method

In a randomized double-blind placebo-controlled study, 56 individuals with AD received 14 days of OSU or placebo treatment. Neuropsychological tasks from the Cambridge Automated Neuropsychological Te

SUBMITTER: Khemiri L 

PROVIDER: S-EPMC6952337 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature