Ontology highlight
ABSTRACT:
SUBMITTER: Li B
PROVIDER: S-EPMC6952391 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nature communications 20200109 1
Host dependency factors that are required for influenza A virus infection may serve as therapeutic targets as the virus is less likely to bypass them under drug-mediated selection pressure. Previous attempts to identify host factors have produced largely divergent results, with few overlapping hits across different studies. Here, we perform a genome-wide CRISPR/Cas9 screen and devise a new approach, meta-analysis by information content (MAIC) to systematically combine our results with prior evid ...[more]