Distinct structure-function relationships across cortical regions and connectivity scales in the rat brain.

ABSTRACT: An improved understanding of the structure-function relationship in the brain is necessary to know to what degree structural connectivity underpins abnormal functional connectivity seen in disorders. We integrated high-field resting-state fMRI-based functional connectivity with high-resolution macro-scale diffusion-based and meso-scale neuronal tracer-based structural connectivity, to obtain an accurate depiction of the structure-function relationship in the rat brain. Our main goal was to identify to what extent structural and functional connectivity strengths are correlated, macro- and meso-scopically, across the cortex. Correlation analyses revealed a positive correspondence between functional and macro-scale diffusion-based structural connectivity, but no significant correlation betwee

SUBMITTER: Straathof M 

PROVIDER: S-EPMC6952407 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature