Type 2 Diabetes Interacts With Alzheimer Disease Risk Factors to Predict Functional Decline.

ABSTRACT:

Objective

The current study examined the interactive effect of type 2 diabetes and Alzheimer disease (AD) risk factors on the rate of functional decline in cognitively normal participants from the Alzheimer's Disease Neuroimaging Initiative.

Methods

Participants underwent annual assessments that included the Functional Activities Questionnaire, an informant-rated measure of everyday functioning. Multilevel modeling, controlling for demographic variables and ischemic risk, examined the interactive effects of diabetes status (diabetes, n=69; no diabetes, n=744) and AD risk factors in the prediction of 5-year longitudinal change in everyday functioning. One model was run for each AD risk factor, including: objectively-defined subtle cognitive decline (Obj-SCD), and genetic susc

SUBMITTER: Thomas KR 

PROVIDER: S-EPMC6952586 | biostudies-literature | 2020 Jan-Mar

REPOSITORIES: biostudies-literature