Multi-Omics Integration Reveals Short and Long-Term Effects of Gestational Hypoxia on the Heart Development.

ABSTRACT: Antenatal hypoxia caused epigenetic reprogramming of methylome and transcriptome in the developing heart and increased the risk of heart disease later in life. Herein, we investigated the impact of gestational hypoxia in proteome and metabolome in the hearts of fetus and adult offspring. Pregnant rats were treated with normoxia or hypoxia (10.5% O₂) from day 15 to 21 of gestation. Hearts were isolated from near-term fetuses and 5 month-old offspring, and proteomics and metabolomics profiling was determined. The data demonstrated that antenatal hypoxia altered proteomics and metabolomics profiling in the heart, impacting energy metabolism, lipid metabolism, oxidative stress, and inflammation-related pathways in a developmental and sex dependent manner. Of importance, integrating

SUBMITTER: Gao Y 

PROVIDER: S-EPMC6952773 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature