Epigenetic Control of Autophagy in Cancer Cells: A Key Process for Cancer-Related Phenotypes.

ABSTRACT: Although autophagy is a well-known and extensively described cell pathway, numerous studies have been recently interested in studying the importance of its regulation at different molecular levels, including the translational and post-translational levels. Therefore, this review focuses on the links between autophagy and epigenetics in cancer and summarizes the. following: (i) how ATG genes are regulated by epigenetics, including DNA methylation and post-translational histone modifications; (ii) how epidrugs are able to modulate autophagy in cancer and to alter cancer-related phenotypes (proliferation, migration, invasion, tumorigenesis, etc.) and; (iii) how epigenetic enzymes can also regulate autophagy at the protein level. One noteable observation was that researchers most often reporte

SUBMITTER: Peixoto P 

PROVIDER: S-EPMC6952790 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature