Flattening of Diluted Species Profile via Passive Geometry in a Microfluidic Device.

ABSTRACT: In recent years, microfluidic devices have become an important tool for use in lab-on-a-chip processes, including drug screening and delivery, bio-chemical reactions, sample preparation and analysis, chemotaxis, and separations. In many such processes, a flat cross-sectional concentration profile with uniform flow velocity across the channel is desired to achieve controlled and precise solute transport. This is often accommodated by the use of electroosmotic flow, however, it is not an ideal for many applications, particularly biomicrofluidics. Meanwhile, pressure-driven systems generally exhibit a parabolic cross-sectional concentration profile through a channel. We draw inspiration from finite element fluid dynamics simulations to design and fabricate a practical solution to achieving a

SUBMITTER: Miles M 

PROVIDER: S-EPMC6952922 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature