RITA Is Expressed in Trophoblastic Cells and Is Involved in Differentiation Processes of the Placenta.

ABSTRACT: Preeclampsia (PE) remains a leading cause of maternal and perinatal mortality and morbidity worldwide. Its pathogenesis has not been fully elucidated and no causal therapy is currently available. It is of clinical relevance to decipher novel molecular biomarkers. RITA (RBP-J (recombination signal binding protein J)-interacting and tubulin-associated protein) has been identified as a negative modulator of the Notch pathway and as a microtubule-associated protein important for cell migration and invasion. In the present work, we have systematically studied RITA's expression in primary placental tissues from patients with early- and late-onset PE as well as in various trophoblastic cell lines. RITA is expressed in primary placental tissues throughout gestation, especially in proliferative vil

SUBMITTER: Wildner JM 

PROVIDER: S-EPMC6953008 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature