The Host Factor Erlin-1 is Required for Efficient Hepatitis C Virus Infection.

ABSTRACT: Development of hepatitis C virus (HCV) infection cell culture systems has permitted the identification of cellular factors that regulate the HCV life cycle. Some of these cellular factors affect steps in the viral life cycle that are tightly associated with intracellular membranes derived from the endoplasmic reticulum (ER). Here, we describe the discovery of erlin-1 protein as a cellular factor that regulates HCV infection. Erlin-1 is a cholesterol-binding protein located in detergent-resistant membranes within the ER. It is implicated in cholesterol homeostasis and the ER-associated degradation pathway. Silencing of erlin-1 protein expression by siRNA led to decreased infection efficiency characterized by reduction in intracellular RNA accumulation, HCV protein expression and virus produ

SUBMITTER: Whitten-Bauer C 

PROVIDER: S-EPMC6953030 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature