Gene Expression Profiles Controlled by the Alternative Splicing Factor Nova2 in Endothelial Cells.

ABSTRACT: Alternative splicing (AS) plays an important role in expanding the complexity of the human genome through the production of specialized proteins regulating organ development and physiological functions, as well as contributing to several pathological conditions. How AS programs impact on the signaling pathways controlling endothelial cell (EC) functions and vascular development is largely unknown. Here we identified, through RNA-seq, changes in mRNA steady-state levels in ECs caused by the neuro-oncological ventral antigen 2 (Nova2), a key AS regulator of the vascular morphogenesis. Bioinformatics analyses identified significant enrichment for genes regulated by peroxisome proliferator-activated receptor-gamma (Ppar-γ) and E2F1 transcription factors. We also showed that Nova2 in ECs contro

SUBMITTER: Belloni E 

PROVIDER: S-EPMC6953062 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature