On-Chip Construction of Multilayered Hydrogel Microtubes for Engineered Vascular-Like Microstructures.

ABSTRACT: Multilayered and multicellular structures are indispensable for constructing functional artificial tissues. Engineered vascular-like microstructures with multiple layers are promising structures to be functionalized as artificial blood vessels. In this paper, we present an efficient method to construct multilayer microtubes embedding different microstructures based on direct fabrication and assembly inside a microfluidic device. This four-layer microfluidic device has two separate inlets for fabricating various microstructures. We have achieved alternating-layered microtubes by controlling the fabrication, flow, and assembly time of each microstructure, and as well, double-layered microtubes have been built by a two-step assembly method. Modifications of both the inner and outer layers was

SUBMITTER: Yue T 

PROVIDER: S-EPMC6953073 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature