Bayesian differential analysis of gene regulatory networks exploiting genetic perturbations.

ABSTRACT:

Background

Gene regulatory networks (GRNs) can be inferred from both gene expression data and genetic perturbations. Under different conditions, the gene data of the same gene set may be different from each other, which results in different GRNs. Detecting structural difference between GRNs under different conditions is of great significance for understanding gene functions and biological mechanisms.

Results

In this paper, we propose a Bayesian Fused algorithm to jointly infer differential structures of GRNs under two different conditions. The algorithm is developed for GRNs modeled with structural equation models (SEMs), which makes it possible to incorporate genetic perturbations into models to improve the inference accuracy, so we name it BFDSEM. Different from the naive

SUBMITTER: Li Y 

PROVIDER: S-EPMC6953167 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature