FOXE1 represses cell proliferation and Warburg effect by inhibiting HK2 in colorectal cancer.

ABSTRACT:

Background

Low expression of FOXE1, a member of Forkhead box (FOX) transcription factor family that plays vital roles in cancers, contributes to poor prognosis of colorectal cancer (CRC) patients. However, the underlying mechanism remains unclear.

Materials and methods

The effects of FOXE1 on the growth of colon cancer cells and the expression of glycolytic enzymes were investigated in vitro and in vivo. Molecular biological experiments were used to reveal the underlying mechanisms of altered aerobic glycolysis. CRC tissue specimens were used to determine the clinical association of ectopic metabolism caused by dysregulated FOXE1.

Results

FOXE1 is highly expressed in normal colon tissues compared with cancer tissues and low expression of FOXE1 is significantly associa

SUBMITTER: Dai W 

PROVIDER: S-EPMC6953170 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature