The Receptor Kinases BAK1/SERK4 Regulate Ca²⁺ Channel-Mediated Cellular Homeostasis for Cell Death Containment.

ABSTRACT: Cell death is a vital and ubiquitous process that is tightly controlled in all organisms. However, the mechanisms underlying precise cell death control remain fragmented. As an important shared module in plant growth, development, and immunity, Arabidopsis thaliana BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 (BAK1) and somatic embryogenesis receptor kinase 4 (SERK4) redundantly and negatively regulate plant cell death. By deploying an RNAi-based genetic screen for bak1/serk4 cell death suppressors, we revealed that cyclic nucleotide-gated channel 20 (CNGC20) functions as a hyperpolarization-activated Ca²⁺-permeable channel specifically regulating bak1/serk4 cell death. BAK1 directly interacts with and phosphorylates CNGC20 at specific sites in the C-terminal cytos

SUBMITTER: Yu X 

PROVIDER: S-EPMC6953177 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature