Trimethylamine-N-oxide has prognostic value in coronary heart disease: a meta-analysis and dose-response analysis.

ABSTRACT: BACKGROUND:Previous clinical studies have suggested that trimethylamine-N-oxide (TMAO) could contribute to the development of atherosclerosis cardiovascular disease. However, the synthetic analysis in coronary heart disease (CHD) was not yet performed. We aimed to clarify the relationship between elevated plasma concentrations of TMAO and the incidence of major adverse cardiovascular events (MACE) in CHD patients. METHODS:Meta-analysis and dose-response analysis of hazard ratio data from prospective observational studies reporting on the association between TMAO plasma concentrations and the incidence of MACE in patients with CHD were conducted. RESULTS:Of the 2369 published articles identified in the search, seven papers, with data from nine cohort studies (10,301 patients), were included

SUBMITTER: Yao ME 

PROVIDER: S-EPMC6953212 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature