Development of an autophagy-related gene prognostic signature in lung adenocarcinoma and lung squamous cell carcinoma.

ABSTRACT:

Purpose

There is plenty of evidence showing that autophagy plays an important role in the biological process of cancer. The purpose of this study was to establish a novel autophagy-related prognostic marker for lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC).

Methods

The mRNA microarray and clinical data in The Cancer Genome Atlas (TCGA) were analyzed by using a univariate Cox proportional regression model to select candidate autophagy-related prognostic genes. Bioinformatics analysis of gene function using the Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) platforms was performed. A multivariate Cox proportional regression model helped to develop a prognostic signature from the pool of candidate genes. On the basis of this progn

SUBMITTER: Zhu J 

PROVIDER: S-EPMC6953332 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature