Predictors of response to insulin therapy in youth with poorly-controlled type 2 diabetes in the TODAY trial.

ABSTRACT:

Objective

To understand the factors associated with glycemic control after starting insulin in youth with type 2 diabetes following glycemic failure (persistent HbA1c ≥8%) with metformin alone, metformin + rosiglitazone or metformin + lifestyle in the TODAY study.

Methods

Change in HbA1c after add-on insulin therapy and the factors predictive of glycemic response were evaluated. At 1-year postinsulin initiation, 253 youth had a mean of 3.9 ± 1.0 visits since the time of insulin initiation. Participants were divided into three groups according to glycemic control: consistent decrease in HbA1c by ≥0.5%, change <0.5%, or consistent increase in HbA1c ≥0.5%, at 75% or more of the visits.

Results

Within 1-year postinsulin initiation, 33.2% of participants had a consistent H

SUBMITTER: Bacha F 

PROVIDER: S-EPMC6953481 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature