Enhanced Striatal Dopamine Release to Expectation of Alcohol: A Potential Risk Factor for Alcohol Use Disorder.

ABSTRACT:

Background

We used positron emission tomography imaging with [¹¹C]raclopride to examine the effects of consumption of alcohol or placebo beverage by participants with alcohol use disorder (AUD) compared with healthy participants with and without family history of AUD. We sought to assess dopamine release following alcohol exposure in relation to AUD risk.

Methods

Three groups were enrolled: participants with AUD (n = 15) and healthy participants with family history negative (n = 34) or positive (n = 16) for AUD. Participants consumed a placebo (n = 65) or alcohol (n = 63) beverage in counterbalanced order before positron emission tomography scanning (128 scans). Binding potential (BP_ND) in the two drink conditions and the percent change in BP_ND

SUBMITTER: Kegeles LS 

PROVIDER: S-EPMC6953614 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature