Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans.

ABSTRACT: Post-traumatic stress disorder (PTSD) is a major problem among military veterans and civilians alike, yet its pathophysiology remains poorly understood. We performed a genome-wide association study and bioinformatic analyses, which included 146,660 European Americans and 19,983 African Americans in the US Million Veteran Program, to identify genetic risk factors relevant to intrusive reexperiencing of trauma, which is the most characteristic symptom cluster of PTSD. In European Americans, eight distinct significant regions were identified. Three regions had values of P < 5 × 10^-10: CAMKV; chromosome 17 closest to KANSL1, but within a large high linkage disequilibrium region that also includes CRHR1; and TCF4. Associations were enriched with respect to the transcriptomic profiles

SUBMITTER: Gelernter J 

PROVIDER: S-EPMC6953633 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature