Deep brain stimulation in treatment resistant schizophrenia: A pilot randomized cross-over clinical trial.

ABSTRACT:

Background

Up to 30% of patients with schizophrenia are resistant to antipsychotic drug treatment, with 60% of such cases also failing to respond to clozapine. Deep brain stimulation (DBS) has been used in treatment resistant patients with other psychiatric disorders, but there is a lack of trials in schizophrenia, partly due to uncertainties over where to site the electrodes. This trial aimed to examine the effectiveness of nucleus accumbens (NAcc) and subgenual anterior cingulate cortex (subgenual ACC) targeted DBS; the primary outcome measure was PANSS total score, as assessed fortnightly.

Methods

Eight patients with schizophrenia, who met criteria for treatment resistance and were also resistant to/intolerant of clozapine, were randomly assigned using central allocation

SUBMITTER: Corripio I 

PROVIDER: S-EPMC6953640 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature