Dataset Information

The Impact of Genes on Adolescent Substance Use: A Developmental Perspective.

ABSTRACT:

Purpose

This review discusses the importance of understanding the impact of genetic factors on adolescent substance use within a developmental framework. Methods for identifying genetic factors, relevant endophenotypes and intermediate phenotypes, and gene-environment interplay effects will be reviewed.

Findings

Prior work supports the role of polygenic variation on adolescent substance use. Mechanisms through which genes impact adolescent phenotypes consist of differences in neural structure and function, early temperamental differences, and problem behavior. Gene-environment interactions are characterized by increased vulnerability to both maladaptive and adaptive contexts.

Summary

Developmental considerations in genetic investigations highlight the critical role that polygenic variation has on adolescent substance use. Yet, determining what to do with this information, especially in terms of personalized medicine, poses ethical and logistic challenges.

SUBMITTER: Trucco EM

PROVIDER: S-EPMC6953736 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Publications

The Impact of Genes on Adolescent Substance Use: A Developmental Perspective.

Trucco Elisa M EM Madan Brigitte B Villar Michelle M

Current addiction reports 20190903 4

<h4>Purpose</h4>This review discusses the importance of understanding the impact of genetic factors on adolescent substance use within a developmental framework. Methods for identifying genetic factors, relevant endophenotypes and intermediate phenotypes, and gene-environment interplay effects will be reviewed.<h4>Findings</h4>Prior work supports the role of polygenic variation on adolescent substance use. Mechanisms through which genes impact adolescent phenotypes consist of differences in neur ...[more]

PMID: 31929960

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Project description:Although lower socioeconomic status has been linked to increased youth substance use, much less research has determined potential mechanisms explaining the association. The current longitudinal study tested whether alternative (i.e., pleasure gained from activities without any concurrent use of substances) and complementary (i.e., pleasure gained from activities in tandem with substance use) reinforcement mediate the link between lower socioeconomic status and youth substance use. Further, we tested whether alternative and complementary reinforcement and youth substance use gradually unfold over time and then intersect with one another in a cascading manner. Potential sex differences are also examined. Data were drawn from a longitudinal survey of substance use and mental health among high school students in Los Angeles. Data collection involved four semiannual assessment waves beginning in fall 2013 (N = 3395; M baseline age = 14.1; 47% Hispanic, 16.2% Asian, 16.1% multiethnic, 15.7% White, and 5% Black; 53.4% female). The results from a negative binomial path model suggested that lower parental socioeconomic status (i.e., lower parental education) was significantly related to an increased number of substances used by youth. The final path model revealed that the inverse association was statistically mediated by adolescents' diminished engagement in pleasurable substance-free activities (i.e., alternative reinforcers) and elevated engagement in pleasurable activities paired with substance use (i.e., complementary reinforcers). The direct effect of lower parental education on adolescent substance use was not statistically significant after accounting for the hypothesized mediating mechanisms. No sex differences were detected. Increasing access to and engagement in pleasant activities of high quality that do not need a reinforcement enhancer, such as substances, may be useful in interrupting the link between lower parental socioeconomic status and youth substance use.

Dataset Information

The Impact of Genes on Adolescent Substance Use: A Developmental Perspective.

Purpose

Findings

Summary

Publications

The Impact of Genes on Adolescent Substance Use: A Developmental Perspective.

Similar Datasets

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