The Impact of Genes on Adolescent Substance Use: A Developmental Perspective.

ABSTRACT:

Purpose

This review discusses the importance of understanding the impact of genetic factors on adolescent substance use within a developmental framework. Methods for identifying genetic factors, relevant endophenotypes and intermediate phenotypes, and gene-environment interplay effects will be reviewed.

Findings

Prior work supports the role of polygenic variation on adolescent substance use. Mechanisms through which genes impact adolescent phenotypes consist of differences in neural structure and function, early temperamental differences, and problem behavior. Gene-environment interactions are characterized by increased vulnerability to both maladaptive and adaptive contexts.

Summary

Developmental considerations in genetic investigations highlight the critical role th

SUBMITTER: Trucco EM 

PROVIDER: S-EPMC6953736 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature