Kidney Damage Biomarkers and Incident Chronic Kidney Disease During Blood Pressure Reduction: A Case-Control Study.

ABSTRACT:

Background

Whether the increased incidence of chronic kidney disease (CKD) during intensive systolic blood pressure (SBP) lowering is accompanied by intrinsic kidney injury is unknown.

Objective

To compare changes in kidney damage biomarkers between incident CKD case participants and matched control participants as well as between case participants in the intensive (<120 mm Hg) versus the standard (<140 mm Hg) SBP management groups of SPRINT (Systolic Blood Pressure Intervention Trial).

Design

Nested case-control study within SPRINT.

Setting

Adults with hypertension without baseline kidney disease.

Participants

Case participants (n = 162), who developed incident CKD during trial follow-up (128 in the intensive and 34 in the standard group), and control p

SUBMITTER: Zhang WR 

PROVIDER: S-EPMC6953744 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature