Neutrophils Deficient in Innate Suppressor IRAK-M Enhances Anti-tumor Immune Responses.

ABSTRACT: Tumor-associated immune-suppressive neutrophils are prevalent in various cancers, including colorectal cancer. However, mechanisms of immune-suppressive neutrophils are not well understood. We report that a key innate suppressor, IRAK-M (interleukin-1 receptor-associated kinase M), is critically involved in the establishment of immune-suppressive neutrophils. In contrast to the wild-type (WT) neutrophils exhibiting immune-suppressive signatures of CD11b^highPD-L1^highCD80^low, IRAK-M-deficient neutrophils are rewired with reduced levels of inhibitory molecules PD-L1 and CD11b, as well as enhanced expression of stimulatory molecules CD80 and CD40. The reprogramming of IRAK-M-deficient neutrophils is mediated by reduced activation of STAT1/3 and enhanced activat

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6953792 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature