High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer.

ABSTRACT: Pancreatic cancer has an extremely poor prognosis, and identification of novel predictors of therapeutic efficacy and prognosis is urgently needed. Chemoresistance-related molecules are correlated with poor prognosis and may be effective targets for cancer treatment. Here, we aimed to identify novel molecules correlated with chemoresistance and poor prognosis in pancreatic cancer. We established 10 patient-derived xenograft (PDX) lines from patients with pancreatic cancer and performed next-generation sequencing (NGS) of tumor tissues from PDXs after treatment with standard drugs. We established a gene-transferred tumor cell line to express chemoresistance-related molecules and analyzed the chemoresistance of the established cell line against standard drugs. Finally, we performed immunohis

SUBMITTER: Ohkuma R 

PROVIDER: S-EPMC6953839 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature