Clinical and pathological features of thrombotic microangiopathy influencing long-term kidney transplant outcomes.

ABSTRACT:

Introduction

Thrombotic microangiopathy (TMA) in post-transplant setting has heterogeneous clinical manifestations.

Methods

We retrospectively studied data of 89 patients with post-transplant TMA, which was characterized by thrombi in at least one glomerulus and/or arteriole. Systemic TMA was defined by thrombocytopenia and microangiopathic anemia and early onset TMA, when occurred less than 90 days post transplant.

Results

The cumulative incidence was 0.93%. The majority of the recipients were young (mean age 39 years), female (52%) and Caucasian (48%) with primary kidney disease of unknown etiology (37%). Early TMA occurred in 51% of the patients and systemic TMA, in 25%. Underlying precipitating factors were: infection (54%), acute rejection (34%), calcineurin inhi

SUBMITTER: Teixeira CM 

PROVIDER: S-EPMC6953866 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature