Microstructural damage of white-matter tracts connecting large-scale networks is related to impaired executive profile in alcohol use disorder.

ABSTRACT: Alcohol Use Disorders (AUD) is associated with negative consequences on global functioning, likely reflecting chronic changes in brain morphology and connectivity. Previous attempts to characterize cognitive impairment in AUD addressed patients' performance in single domains, without considering their cognitive profile as a whole. While altered cognitive performance likely reflects abnormal white-matter microstructural properties, to date no study has directly addressed the relationship between a proxy of patients' cognitive profile and microstructural damage. To fill this gap we aimed to characterize the microstructural damage pattern, and its relationship with cognitive profile, in treatment-seeking AUD patients. Twenty-two AUD patients and 18 healthy controls underwent a multimodal MRI

SUBMITTER: Crespi C 

PROVIDER: S-EPMC6953958 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature