Optimal Management of Upper Tract Urothelial Carcinoma: Current Perspectives.

ABSTRACT:

Introduction

Upper tract urothelial carcinoma (UTUC) is a relatively uncommon urologic malignancy for which there has not been significant improvement in survival over the past few decades, highlighting the need for optimal multi-modality management.

Methods

A non-systematic review of the latest literature was performed to include relevant articles up to June 2019. It summarizes the epidemiologic risk factors associated with UTUC, including smoking, carcinogenic aromatic amines, arsenic, aristolochic acid, and Lynch syndrome. Molecular pathways underlying UTUC and potential druggable targets are outlined.

Results

Surgical management for UTUC includes kidney-sparing surgery (KSS) for low-risk disease and radical nephroureterectomy (RNU) for high-risk disease. Endoscopi

SUBMITTER: Leow JJ 

PROVIDER: S-EPMC6954076 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature