Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4⁺ T Cell Immunity.

ABSTRACT: Differentiation of proinflammatory CD4⁺ conventional T cells (T_conv) is critical for productive antitumor responses yet their elicitation remains poorly understood. We comprehensively characterized myeloid cells in tumor draining lymph nodes (tdLN) of mice and identified two subsets of conventional type-2 dendritic cells (cDC2) that traffic from tumor to tdLN and present tumor-derived antigens to CD4⁺ T_conv, but then fail to support antitumor CD4⁺ T_conv differentiation. Regulatory T cell (T_reg) depletion enhanced their capacity to elicit strong CD4⁺ T_conv responses and ensuing antitumor protection. Analogous cDC2 populations were identified in patients, and as in mice, their abundance relativ

SUBMITTER: Binnewies M 

PROVIDER: S-EPMC6954108 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature