Exploring genetic targets of psoriasis using genome wide association studies (GWAS) for drug repurposing.

ABSTRACT: Psoriasis is a chronic inflammatory disease causing itching in the body and pain in the joints. Currently, no permanent cure is available at a commercial level for this disease. Genome wide association studies (GWAS) provide a deeper insight that helps in better understanding this disease and further possible cure of this disease. The major goal of the present study is to identify potent genetic targets of psoriasis disease using GWAS approach and identify drugs for repurposing. The methods used include GWAS catalogue, GeneAnalytics, canSAR protein annotation tool, VarElect, Drug bank, Proteomics database, ProTox software. By exploring GWAS catalogue, 126 psoriasis associated genes (PAG) were identified. 68 genes found to be druggable were obtained from canSAR protein annotation tool. Loca

SUBMITTER: Nanda H 

PROVIDER: S-EPMC6954159 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature