Ontology highlight
ABSTRACT:
SUBMITTER: Nepal C
PROVIDER: S-EPMC6954239 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nature communications 20200110 1
Variations in transcription start site (TSS) selection reflect diversity of preinitiation complexes and can impact on post-transcriptional RNA fates. Most metazoan polymerase II-transcribed genes carry canonical initiation with pyrimidine/purine (YR) dinucleotide, while translation machinery-associated genes carry polypyrimidine initiator (5'-TOP or TCT). By addressing the developmental regulation of TSS selection in zebrafish we uncovered a class of dual-initiation promoters in thousands of gen ...[more]