Diagnosis of Bovine Respiratory Disease in feedlot cattle using blood ¹H NMR metabolomics.

ABSTRACT: Current diagnosis methods for Bovine Respiratory Disease (BRD) in feedlots have a low diagnostic accuracy. The current study aimed to search for blood biomarkers of BRD using ¹H NMR metabolomics and determine their accuracy in diagnosing BRD. Animals with visual signs of BRD (n = 149) and visually healthy (non-BRD; n = 148) were sampled for blood metabolomics analysis. Lung lesions indicative of BRD were scored at slaughter. Non-targeted ¹H NMR metabolomics was used to develop predictive algorithms for disease classification using classification and regression trees. In the absence of a gold standard for BRD diagnosis, six reference diagnosis methods were used to define an animal as BRD or non-BRD. Sensitivity (Se) and specificity (Sp) were used to estimate diagnostic

SUBMITTER: Blakebrough-Hall C 

PROVIDER: S-EPMC6954258 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature