Clinical Factors Associated with Urinary Tract Cancer in Individuals with Lynch Syndrome.

ABSTRACT:

Background

Lynch syndrome confers markedly increased risks of various malignancies, including urinary tract cancers (UTC; renal pelvis, ureter, bladder, and possibly kidney cancers). It is unknown how to determine which Lynch syndrome carriers are at highest UTC risk. Our aim was to identify clinical factors associated with UTC among Lynch syndrome carriers.

Methods

The study population was a cohort of 52,758 consecutively ascertained individuals undergoing Lynch syndrome testing at a commercial laboratory. Clinical data were obtained from test request forms completed by the ordering provider. Univariate analysis and multivariate logistic regression were performed to identify factors associated with UTC among Lynch syndrome carriers.

Results

Compared with noncarriers,

SUBMITTER: Wischhusen JW 

PROVIDER: S-EPMC6954282 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature