Compensatory Hippocampal Recruitment Supports Preserved Episodic Memory in Autism Spectrum Disorder.

ABSTRACT:

Background

The degree to which individuals with autism spectrum disorder (ASD) evidence impairments in episodic memory relative to their typically developing (TD) counterparts remains unclear. According to a prominent view, ASD is associated with deficits in encoding associations between items and recollecting precise context details. Here, we evaluated behavioral and neural evidence for this impaired relational binding hypothesis using a task involving relational encoding and recollection during functional magnetic resonance imaging.

Methods

Adolescents and young adults (n_ASD = 47, n_TD = 60) performed the Relational and Item-Specific Encoding task during functional magnetic resonance imaging, including item and associative recognition testing. We model

SUBMITTER: Hogeveen J 

PROVIDER: S-EPMC6954323 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature