Δ⁹-Tetrahydrocannabinol During Encoding Impairs Perceptual Details yet Spares Context Effects on Episodic Memory.

ABSTRACT:

Background

With the growing acceptance of cannabis use, it is crucial to understand the drug's effects on episodic memory accuracy and distortion. We investigated the impact of the administration of Δ⁹-tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis, on a context-based memory illusion.

Methods

In a double-blind, placebo-controlled, within-subjects design, healthy infrequent cannabis users (N = 24) memorized object pictures that were superimposed over scenes (e.g., gray cat on beach) after pretreatment with placebo or THC (15 mg oral). Two days later under sober conditions, memory for the object pictures was tested by asking participants to discriminate between previously seen objects or perceptually similar lures (e.g., different gray cat

SUBMITTER: Doss MK 

PROVIDER: S-EPMC6954333 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature