An evaluation of supervised methods for identifying differentially methylated regions in Illumina methylation arrays.

ABSTRACT: Epigenome-wide association studies (EWASs) have become increasingly popular for studying DNA methylation (DNAm) variations in complex diseases. The Illumina methylation arrays provide an economical, high-throughput and comprehensive platform for measuring methylation status in EWASs. A number of software tools have been developed for identifying disease-associated differentially methylated regions (DMRs) in the epigenome. However, in practice, we found these tools typically had multiple parameter settings that needed to be specified and the performance of the software tools under different parameters was often unclear. To help users better understand and choose optimal parameter settings when using DNAm analysis tools, we conducted a comprehensive evaluation of 4 popular DMR analysis tools

SUBMITTER: Mallik S 

PROVIDER: S-EPMC6954393 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature