WHO grade has no prognostic value in the pediatric high-grade glioma included in the HERBY trial.

ABSTRACT:

Background

The World Health Organization (WHO) adult glioma grading system is questionable in pediatric high-grade gliomas (pHGGs), which are biologically distinct from adult HGGs. We took advantage of the neuropathological review data obtained during one of the largest prospective randomized pHGG trials, namely HERBY (NCT01390948), to address this issue in children with newly diagnosed non-brainstem HGG.

Methods

HGG diagnosis was confirmed by pre-randomization, real-time central pathology review using WHO 2007 criteria, followed by a consensus review blinded to clinical factors and outcomes. We evaluated association between WHO 2007 grade and other clinical/radiological/biological characteristics and the prognostic value of WHO 2007 grade, midline location, and selected bio

SUBMITTER: Varlet P 

PROVIDER: S-EPMC6954414 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature