MitoXplorer, a visual data mining platform to systematically analyze and visualize mitochondrial expression dynamics and mutations.

ABSTRACT: Mitochondria participate in metabolism and signaling. They adapt to the requirements of various cell types. Publicly available expression data permit to study expression dynamics of genes with mitochondrial function (mito-genes) in various cell types, conditions and organisms. Yet, we lack an easy way of extracting these data for mito-genes. Here, we introduce the visual data mining platform mitoXplorer, which integrates expression and mutation data of mito-genes with a manually curated mitochondrial interactome containing ∼1200 genes grouped in 38 mitochondrial processes. User-friendly analysis and visualization tools allow to mine mitochondrial expression dynamics and mutations across various datasets from four model species including human. To test the predictive power of mitoXplorer, w

SUBMITTER: Yim A 

PROVIDER: S-EPMC6954439 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature